Finally, books on scientifi c research talk a lot about fascination, thirst of knowledge, and enthusiasm. You fi nd little on endless pipetting, failed experiments, and lack of funding. Many years’ work often leads only to the discovery that there is nothing to discover in the direction taken. Only luck, diligence, ingenuity, good mentoring, and intelligence—in this order—bring success at the lab bench. Thus, your adventures will resemble those of the knight errant: every day and Sunday you take your tottery Rosinante to a castle where the king is diffi cult, the efforts great, the results bewildering

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